Role of flupirtine in the treatment of pain - chemistry and its effects.
نویسندگان
چکیده
163 Maedica A Journal of Clinical Medicine, Volume 7 No.2 2012 Role of Flupirtine in the Treatment of Pain Chemistry and its Effects Rikki SINGALa, MS, FICS, FAIS; Parveen GUPTAb, MD; Nidhi JAINc, MD; Samita GUPTAd aDepartment of Surgery Maharishi Markandeshwer Institute of Medical Sciences and Research, Mullana, (Distt-Ambala), Haryana, India E bDepartment of Medicine Maharishi Markandeshwer Institute of Medical Sciences and Research, Mullana, (Distt-Ambala), Haryana, India cDepartment of Pathology Maharishi Markandeshwer Institute of Medical Sciences and Research, Mullana, (Distt-Ambala), Haryana, India dDepartment of Radiodiagnosis and Imaging Maharishi Markandeshwer Institute of Medical Sciences and Research, India
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A Study of Chemistry and Antinociceptive Properties of Medicinal Plant Allium Jesdianum Leaves and the Probable Role of Opioidergic System
Khaksarian M1, Meshkatosadat MH2, Farzi R3, Safarpour F3 1. Instructor, Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences 2. Associate Professor, Department of Chemistry, Faculty of Basic sciences, Lorestan University 3. M.Sc of Physiology, Staff member of Neurology Sciences Research Center, Kerman University of Medical Sciences Abstract Backgr...
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OBJECTIVE Flupirtine is a non-opioid analgesic without antipyretic or antiphlogistic properties but with favorable tolerability in humans. This analgesic also exhibits neuroprotective activities. Furthermore, flupirtine antagonizes glutamate- and NMDA-induced intracellular levels of Ca(2+) and counteracts the effects of focal cerebral ischemia. Although flupirtine has been used to relieve pain ...
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Background Flupirtine is a centrally acting, non-opioid analgesic with muscle relaxant and neuroprotective properties. Although routinely used in the clinic, its mechanism of action remained poorly understood; it had been suggested to antagonize NMDA receptors and to activate G proteincoupled inward rectifier (GIRK) and KCNQ K+ channels. Since spinal GABAA receptors are involved in pain sensati...
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BACKGROUND Effective control of pain postoperatively is essential in providing enhanced patient care and a cost-effective hospital stay. Though many treatment modalities exist for postoperative pain management in orthopedic surgeries they are often accompanied by adverse effects. This study was carried out to assess the efficacy of flupirtine and piroxicam in postoperative pain reduction using ...
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Calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. In the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. Orofacial pain was induced by subcutaneous (SC) injection of for...
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عنوان ژورنال:
- Maedica
دوره 7 2 شماره
صفحات -
تاریخ انتشار 2012